NAD+

Nicotinamide adenine dinucleotide (NAD+) is a molecule that helps cells produce energy and repair DNA. It’s also involved in regulating gene expression and other cellular functions.

Function:

Energy metabolism: NAD+ is a key component of energy metabolism, helping cells produce ATP
DNA repair: NAD+ helps repair DNA and protect the genome from hypermethylation
Gene expression: NAD+ helps regulate gene expression by affecting the activity of enzymes that modify DNA
Cellular senescence: NAD+ levels decline with age, which can contribute to aging-related diseases

Studies have found that NAD+ supplementation has significantly decreased and/or maintained BMI in patients that combine it with regular diet and exercise. This nonhormonal coenzyme helps the body increase adiponectin, a protein hormone that allows the body to break down excess carbs and fat. NAD+ levels decrease significantly as we age, so this supplement is especially helpful for older individuals that are interested in maintaining their metabolism as they age.

References

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1208734/full

https://pubmed.ncbi.nlm.nih.gov/37854354/

https://www.sciencedirect.com/science/article/pii/S0955286322001279